SLC23A2

SLC23A2
Identifiers
Aliases	SLC23A2, NBTL1, SLC23A1, SVCT2, YSPL2, hSVCT2, solute carrier family 23 member 2
External IDs	OMIM: 603791; MGI: 1859682; HomoloGene: 68440; GeneCards: SLC23A2; OMA:SLC23A2 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	5,010,293 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	131,987,028 bp
RNA expression pattern
	Top expressed in
	right adrenal cortex; ; left adrenal cortex; ; lateral nuclear group of thalamus; ; Brodmann area 10; ; Epithelium of choroid plexus; ; paraflocculus of cerebellum; ; cerebellar vermis; ; pars compacta; ; right lobe of liver; ; subthalamic nucleus;
	Top expressed in
	choroid plexus of fourth ventricle; ; secondary oocyte; ; gastrula; ; zygote; ; primary visual cortex; ; perirhinal cortex; ; CA3 field; ; entorhinal cortex; ; Epithelium of choroid plexus; ; superior frontal gyrus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	nucleobase transmembrane transporter activity; transporter activity; L-ascorbate:sodium symporter activity; symporter activity; L-ascorbic acid transmembrane transporter activity; transmembrane transporter activity;
Cellular component	cytoplasm; membrane; basal plasma membrane; basolateral plasma membrane; apical plasma membrane; plasma membrane; integral component of plasma membrane; integral component of membrane; contractile fiber;
Biological process	sodium ion transport; ion transport; response to oxidative stress; L-ascorbic acid transmembrane transport; nucleobase transport; transmembrane transport; nucleobase-containing compound metabolic process; L-ascorbic acid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	百度」习近平临场不经意的几句话，恰恰就点中了中国新一个阶段经济发展的要害，也为几年前提出的「供给侧改革」提供了最佳注解。 9962
	54338
	ENSG00000089057
	ENSMUSG00000027340
	Q9UGH3
	Q9EPR4
	NM_005116; NM_203327
	NM_018824; NM_001355430; NM_001355431
	NP_005107; NP_976072
	NP_061294; NP_001342359; NP_001342360
	Wikidata
View/Edit Human	View/Edit Mouse

Solute carrier family 23 member 2 is a protein that in humans is encoded by the SLC23A2 gene.^[5]^[6]^[7]

The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two required transporters and the encoded protein accounts for tissue-specific uptake of vitamin C. Previously, this gene had an official symbol of SLC23A1.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000089057 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027340 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Faaland CA, Race JE, Ricken G, Warner FJ, Williams WJ, Holtzman EJ (Dec 1998). "Molecular characterization of two novel transporters from human and mouse kidney and from LLC-PK1 cells reveals a novel conserved family that is homologous to bacterial and Aspergillus nucleobase transporters". Biochim Biophys Acta. 1442 (2–3): 353–60. doi:10.1016/S0167-4781(98)00151-1. PMID 9804989.
^ Tsukaguchi H, Tokui T, Mackenzie B, Berger UV, Chen XZ, Wang Y, Brubaker RF, Hediger MA (Jun 1999). "A family of mammalian Na+-dependent L-ascorbic acid transporters". Nature. 399 (6731): 70–5. Bibcode:1999Natur.399...70T. doi:10.1038/19986. PMID 10331392. S2CID 4425479.
^ ^a ^b "Entrez Gene: SLC23A2 solute carrier family 23 (nucleobase transporters), member 2".

Liang WJ, Johnson D, Jarvis SM (2001). "Vitamin C transport systems of mammalian cells". Mol. Membr. Biol. 18 (1): 87–95. doi:10.1080/09687680110033774. PMID 11396616. S2CID 22478598.
Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
Hogue DL, Ling V (1999). "A human nucleobase transporter-like cDNA (SLC23A1): member of a transporter family conserved from bacteria to mammals". Genomics. 59 (1): 18–23. doi:10.1006/geno.1999.5847. PMID 10395795.
Rajan DP, Huang W, Dutta B, et al. (1999). "Human placental sodium-dependent vitamin C transporter (SVCT2): molecular cloning and transport function". Biochem. Biophys. Res. Commun. 262 (3): 762–8. doi:10.1006/bbrc.1999.1272. PMID 10471399.
Daruwala R, Song J, Koh WS, et al. (1999). "Cloning and functional characterization of the human sodium-dependent vitamin C transporters hSVCT1 and hSVCT2". FEBS Lett. 460 (3): 480–4. doi:10.1016/S0014-5793(99)01393-9. PMID 10556521. S2CID 37936975.
Breton S, Wiederhold T, Marshansky V, et al. (2000). "The B1 subunit of the H+ATPase is a PDZ domain-binding protein. Colocalization with NHE-RF in renal B-intercalated cells". J. Biol. Chem. 275 (24): 18219–24. doi:10.1074/jbc.M909857199. PMID 10748165.
Holliday LS, Lu M, Lee BS, et al. (2000). "The amino-terminal domain of the B subunit of vacuolar H+-ATPase contains a filamentous actin binding site". J. Biol. Chem. 275 (41): 32331–7. doi:10.1074/jbc.M004795200. PMID 10915794.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
Hediger MA (2002). "New view at C.". Nat. Med. 8 (5): 445–6. doi:10.1038/nm0502-445. PMID 11984580. S2CID 787845.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Fischer H, Schwarzer C, Illek B (2004). "Vitamin C controls the cystic fibrosis transmembrane conductance regulator chloride channel". Proc. Natl. Acad. Sci. U.S.A. 101 (10): 3691–6. Bibcode:2004PNAS..101.3691F. doi:10.1073/pnas.0308393100. PMC 373524. PMID 14993613.
Lutsenko EA, Carcamo JM, Golde DW (2004). "A human sodium-dependent vitamin C transporter 2 isoform acts as a dominant-negative inhibitor of ascorbic acid transport". Mol. Cell. Biol. 24 (8): 3150–6. doi:10.1128/MCB.24.8.3150-3156.2004. PMC 381605. PMID 15060139.
Seno T, Inoue N, Matsui K, et al. (2004). "Functional expression of sodium-dependent vitamin C transporter 2 in human endothelial cells". J. Vasc. Res. 41 (4): 345–51. doi:10.1159/000080525. PMID 15340249. S2CID 20754421.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
McNulty AL, Vail TP, Kraus VB (2005). "Chondrocyte transport and concentration of ascorbic acid is mediated by SVCT2". Biochim. Biophys. Acta. 1712 (2): 212–21. doi:10.1016/j.bbamem.2005.04.009. PMID 15921655.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000089057 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027340 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9804989-5] Faaland CA, Race JE, Ricken G, Warner FJ, Williams WJ, Holtzman EJ (Dec 1998). "Molecular characterization of two novel transporters from human and mouse kidney and from LLC-PK1 cells reveals a novel conserved family that is homologous to bacterial and Aspergillus nucleobase transporters". Biochim Biophys Acta. 1442 (2–3): 353–60. doi:10.1016/S0167-4781(98)00151-1. PMID 9804989.

[pmid10331392-6] Tsukaguchi H, Tokui T, Mackenzie B, Berger UV, Chen XZ, Wang Y, Brubaker RF, Hediger MA (Jun 1999). "A family of mammalian Na+-dependent L-ascorbic acid transporters". Nature. 399 (6731): 70–5. Bibcode:1999Natur.399...70T. doi:10.1038/19986. PMID 10331392. S2CID 4425479.

[entrez-7] "Entrez Gene: SLC23A2 solute carrier family 23 (nucleobase transporters), member 2".

[1]

[2]

[3]

[4]

[5]

[6]

[7]

床垫什么样的好	纸上谈兵是什么生肖	唏嘘不已的意思是什么	肚脐眼周围痛挂什么科	酸奶什么时候喝好
生活惬意是什么意思	瑗是什么意思	射手女喜欢什么样的男生	每次上大便都出血是什么原因	银屑病为什么会自愈
红斑是什么皮肤病	干咳无痰是什么原因引起的	绝什么意思	absolue是兰蔻的什么产品	香辛料是什么
卵巢筛查要做什么检查	速度等于什么	梦见自己坐火车是什么意思	死马当活马医是什么意思	脚疼挂什么科

性出血是什么原因造成的呢要怎么办hcv8jop3ns9r.cn	势利眼是什么意思hcv8jop1ns4r.cn	在减肥期间吃什么最好hcv8jop5ns6r.cn	天丝是什么材质hcv7jop5ns0r.cn	什么人不能吃马齿苋hcv8jop1ns4r.cn
减肥期间吃什么最好jasonfriends.com	考妣是什么意思hcv7jop4ns6r.cn	工夫是什么意思hcv9jop4ns6r.cn	念珠菌性阴道炎有什么症状hcv9jop0ns4r.cn	褶子是什么意思hlguo.com
大什么大hcv8jop0ns5r.cn	子宫脱落是什么原因引起的hcv7jop7ns2r.cn	一直发低烧是什么原因kuyehao.com	心脏由什么组织构成hcv8jop9ns0r.cn	7月7号是什么节日hcv9jop6ns6r.cn
撸猫是什么意思hcv9jop7ns3r.cn	发低烧吃什么药hcv9jop7ns3r.cn	尿偏红色是什么原因hcv8jop4ns6r.cn	癸丑五行属什么hcv9jop1ns0r.cn	仁慈是什么意思hcv8jop6ns6r.cn

“雷霆之子”自动扶正艇——“海上不倒翁” 3秒“翻身仗”

See also

References

Further reading